@font-face{font-family:EB Garamond;font-style:normal;font-weight:400 800;font-display:swap;src:url(/fonts/eb-garamond-latin-var.woff2) format("woff2")}@font-face{font-family:Lato;font-style:normal;font-weight:400;font-display:swap;src:url(/fonts/lato-latin-400.woff2) format("woff2")}@font-face{font-family:Lato;font-style:normal;font-weight:700;font-display:swap;src:url(/fonts/lato-latin-700.woff2) format("woff2")}:root{--arp-sticky-header-h:56px;--arp-page-max:1320px;--arp-page-pad:1.25rem}@media (min-width:1024px){:root{--arp-page-pad:2rem}}.arp-container{max-width:var(--arp-page-max);padding-inline:var(--arp-page-pad)}.arp-h1{letter-spacing:-.012em}.arp-h1,.arp-h2{font-weight:600}.pub-h1{font-size:clamp(2rem,1.4vw + 1.45rem,2.625rem);line-height:1.1;letter-spacing:-.012em}.pub-h1,.pub-h2{font-family:var(--font-serif);font-weight:600;color:var(--arp-ink-900)}.pub-h2{font-size:clamp(1.375rem,.7vw + 1.1rem,1.75rem);line-height:1.2;letter-spacing:-.005em}.pub-h3{font-weight:700;font-size:1.0625rem;line-height:1.35;color:var(--arp-ink-900);letter-spacing:0}.pub-body,.pub-h3{font-family:var(--font-sans)}.pub-body{font-size:.9375rem;line-height:1.6;color:var(--arp-ink-700)}.pub-meta{font-size:.8125rem;line-height:1.45}.pub-label,.pub-meta{font-family:var(--font-sans);color:var(--arp-ink-500)}.pub-label{font-size:.75rem;line-height:1.2;font-weight:700;letter-spacing:.08em;text-transform:uppercase}[data-section-anchor]{scroll-margin-top:calc(var(--arp-sticky-header-h) + 56px)}@media (prefers-reduced-motion:no-preference){html{scroll-behavior:smooth}}@keyframes pharmacovigilance-alert-pulse{0%,to{box-shadow:0 0 0 0 rgba(179,38,30,.55)}50%{box-shadow:0 0 0 8px rgba(179,38,30,0)}}.pharmacovigilance-alert{animation:pharmacovigilance-alert-pulse 1.8s ease-out infinite}.pharmacovigilance-icon{animation:pharmacovigilance-icon-nudge 1.8s ease-in-out infinite}@keyframes pharmacovigilance-icon-nudge{0%,to{transform:scale(1)}50%{transform:scale(1.18)}}@media (prefers-reduced-motion:reduce){.pharmacovigilance-alert,.pharmacovigilance-icon{animation:none}}:root{--arp-dock-clearance:calc(8rem + env(safe-area-inset-bottom, 0px));--arp-dock-footprint-x:calc(1rem + 44px + 0.75rem)}@media (min-width:640px){:root{--arp-dock-clearance:calc(9.5rem + env(safe-area-inset-bottom, 0px));--arp-dock-footprint-x:calc(1.5rem + 52px + 0.75rem)}}@media (min-width:1440px){:root{--arp-dock-clearance:0px}}:root{--arp-dock-intrusion:max(0px,calc(var(--arp-dock-footprint-x) - max(var(--arp-page-pad), calc((100vw - var(--arp-page-max)) / 2 + var(--arp-page-pad)))))}html{scroll-padding-bottom:var(--arp-dock-clearance)}.arp-dock-clearance{padding-bottom:var(--arp-dock-clearance)}